Center for Structural Biology
Laufer Center for Physical and Quantitative Biology
The Louis and Beatrice Laufer Center is a hub for research in Physical and Quantitative Biology at Stony Brook University. We aim to advance biology and medicine through discoveries in physics, mathematics and computational science.
Our research is diverse. Laufer Center researchers insert gene circuits into cells and study noise. We insert barcodes to study evolution, cell-by-cell. Some of us use computational modeling to understand how proteins fold and how proteins bind to proteins and design drugs for high-affinity binding to proteins. We explore how protein motions cause biological mechanisms and how proteins aggregate in neurodegenerative diseases such as Parkinson’s and Alzheimer’s. And, some of us use computers to design vaccines.
Laufer Center researchers come from a broad community including Stony Brook departments of chemistry, physics, applied mathematics and statistics, computer science, molecular genetics and microbiology as well as Cold Spring Harbor Laboratory.
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Institute for Drug Discovery and Chemical Biology
ICB&DD complements Stony Brook’s Centers for Molecular Medicine (CMM) and significantly contribute to the establishment of a truly comprehensive biomedical research enterprise from molecular science to clinic at Stony Brook. Fundamental biological research often fails to include drug discovery, which is one of the most important and beneficial scientific contributions to mankind.
The primary objective of ICB&DD is to establish a world-class “Center of Excellence” in chemical biology and drug discovery at Stony Brook University. The rapid and impressive advancements in chemical biology during the last decade have clearly demonstrated that solutions for a vast majority of medical problems rely on the understanding of the molecular basis of diseases, therapeutic targets, drug actions, and drug resistance. ICB&DD promotes highly productive interdisciplinary and collaborative research among chemists, biologists, medicinal chemists, pharmacologists, and physicians to attack major biomedical problems to find solutions including the discovery of novel therapeutic drugs.
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Brookhaven National Laboratory
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Other Facilities
In addition, research laboratories in the CSB are well equipped with biophysical instrumentation for Fourier transform infrared, fluorescence, and circular dichroism spectroscopy, as well as atomic force microscopy. A number of core facilities also support and enhance the research productivity of investigators at in the BSB program. These include the Center for Analysis and Sequencing of Macromolecules (CASM); a DNA sequencing facility; a mass spectrometer facility; the University Microscopy Imaging Center (UMIC), with high-resolution equipment for performing light, confocal microscopy, and transmission/scanning electron microscopy; numerous shared computer facilities; a transgenic mouse facility; a spacious and expertly operated animal research laboratory; a monoclonal antibody tissue culture center; and a microarray facility.
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